Publications

SELECT: 2030 – 2026 | 2025 – 2021 | 2020 – 2016 | 2015 – 2011 | 2010 – 2006 | 2005 – 1999

(110) A. R. Bucknam, J. M. Nicholson, H. S. Radomska, G. M. Young, C. C. Coss, G. C. Micalizio “An Estrogen Receptor β Agonist with AR Antagonist Activity from a Modern Asymmetric De Novo Steroid Synthesis” ACS Med. Chem. Lett. 2025, 16, 631–637.

(109) J. M. Nicholson, D. Yang, T. Koelblen, E. L. Hu, C. C. Coss, T. P. Burris, X. Hu, G. C. Micalizio “Merging Natural Product Structures with Pharmaceutical Leads: Unnatural Enantiomers of Estranes as Glucocorticoid Receptor Modulators that Suppress TNF-alpha and IL-6 Release” J. Med. Chem. 2024, 67, 16185–16194.

(108) Z. D. Stempel, H. S. Radomska, C. C. Coss, G. C. Micalizio ” Function-Oriented Synthesis of Pentacyclic Triterpenoids and Discovery of an ent-Estrane as a Natural Product-Inspired Androgen Receptor Antagonist” Org. Lett. 2024, 26, 3054–3059.

(107) T. J. Fazekus and G. C. Micalizio “Progress Toward the Asymmetric De Novo Synthesis of Limonoids” Org. Lett. 2024, 26, 1073–1076.

(106) L. E. Markham, T. Koelblen, H. R. Chobanian, A. Viacava Follis, T. P. Burris, G. C. Micalizio “From Functional Fatty Acids to Potent and Selective Natural Product-Inspired Mimetics via Conformational Profiling” ACS Central Science, 2024, 10, 477–486.

Recent Patent Publications

(105) C19 Scaffold and Steroids and Methods of Use and Manufacture Thereof (US2021 10323998A1).

(104) Steroids and Methods of Manufacture (US2023 0018615A1).

(103) Chiral Oligomeric Pentenoate Amide as Bio-Oligomer Mimetics (US9963481B2)

(102) Glucocorticoid Receptor Modulators (US2023 0212215A1)

(101) Liver X Receptor Modulators (WO2022 241404A1)

(100) Androgen Receptor Modulators (WO2021 188415A1 ; WO2022198191A1)

(99) Methods for Assembly of Tetracyclic Compounds by Stereoselective C9–C10 Bond Formation (US2023 0151053A1; US20210188898A1)

(98) Therapeutic Uses of Glucocorticoids with Anabolic Effects in Skeletal Muscle (US2023 0263808A1 ; WO2022 081725A1)

(97) Methods for Convenient Asymmetric Synthesis of C9-Substituted Steroid-like Compounds (WO2022 198224A1)

(96) Stereoselective C9–C10 Bond Formation (WO2022 226473A1)

(95) J. M. Nicholson, G. C. Micalizio, “Asymmetric Total Syntheses of Euphol and Tirucallol” Org. Lett. 2023, 25, 5687–5691.

(94) A. R. Bucknam, G. C. Micalizio, “Progress Toward the Asymmetric de Novo Synthesis of Lanostanes: A Counter Biomimetic Cucurbitane-to-Lanostane Type Transformation” Tetrahedron (virtual issue in honor of Professor John L. Wood), 2023, 141, 133498.

(93) H. T. Wai, G. C. Micalizio, ” Toward the Asymmetric De Novo Synthesis of Lanostanes: Construction of 7,11-dideoxy-D5-lucidadone H” J. Org. Chem. 2022, 87, 14975-14979.

(92) A. B. Millham, G. C. Micalizio, “Toward the Asymmetric Synthesis of Cardenolides and Related Steroidal Systems: syn-SN2′ of Organometallics with C14–C17 Vinyelepoxides” Org. Lett. 2022, 24, 7058-7061.

(91) H.T. Wai, T. Koelblen, M. E. Hayes, T. P. Burris, G. C. Micalizio, “Progress Toward the De Novo Asymmetric Synthesis of Euphanes” Org. Lett. 2022, 24, 3686-3690.

(90) A. R. Bucknam, G. C. Micalizio “Asymmetric De Novo Synthesis of a Cucurbitane Triterpenoid: Total Synthesis of Octanorcucurbitacin B” J. Am. Chem. Soc. 2022, 144, 8493-8497.

(89) J. M. Nicholson, A. B. Millham, A. R. Bucknam, L. E. Markham, X. E. Sailors, G. C. Micalizio, “A General Enantioselective and Stereochemically Divergent Four-Stage Approach to Fused Tetracyclic Terpenoid Systems” J. Org. Chem. 2022, 87, 3352-3362.

(88) L. E. Markham, J. D. Tolbert, F. J. Kull, C. R. Midgett, G. C. Micalizio, “An Enantiodefined Conformationally Constrained Fatty Acid Mimetic and Potent Inhibitor of ToxT” ACS Med. Chem. Lett. 2021, 12, 1493-1497.

(87) Z. A. Shalit, L. Valdes, W. S. Kim, G. C. Micalizio, “From an ent-Estrane, Through a nat-Androstane, to the Total Synthesis of the Marine-Derived Δ8,9-Pregnene (+)-03219A” Org. Lett. 2021, 23, 2248-2252.